Zearalenone and fusariosis?

I just received the results from the first mycotoxin lab work I’ve done and it explains a lot. My doc, to her great credit, has been pushing me to do this test for several years, probably from my first appointment with her and I finally got it done. Why did I delay? I always suspected I was suffering from a mold colonization and of course the test is not covered by insurance! So my thinking was that I should eliminate my intestinal fungal infections and then do the test. But cleaning my gut has taken years and still isn’t done.

My MD even diagnosed me with CIRS which is either caused by mold toxicity or Lyme (or maybe both) and I was hoping my case was just Lyme related. Still I postponed the mycotoxin test, grrrrrr.

You’ll see all of the mold toxins I have are immunotoxic, immunosuppressive and or hepatotoxic. Zearalenone is off the charts and that is the one that is hepatotoxic which might help explain why my efforts to clear infections have always been so difficult and so often were ended by migraines…

Wish I had done this test years ago. My Dr. has been saying for years that I wouldn’t get rid of any of my infections (Lyme etc) so long as I’m mold toxic.

Note, the test result description says:

ZEA is deactivated primarily through glucuronidation; individuals with impairment to this pathway will be much more susceptible to this compound even at very low levels. Well here’s my livewello glucuronidation SNP report:

 

Interestingly, zearalenone or ZEA is a toxin produced by fusarium fungi that does colonize humans (called fusariosis) and maybe that’s why my level is extreme. Or maybe the test is just picking up ZEA from my daily coffee enemas. At $300 a pop, I’m not sure I’ll do enough retesting to ever know the source.

Fusarium infections in immunocompromised patients

Fusarium species cause a broad spectrum of infections in humans, including superficial, locally invasive, and disseminated infections. The clinical form of fusariosis depends largely on the immune status of the host and the portal of entry, with superficial and localized disease occurring mostly in immunocompetent patients and invasive and disseminated disease affecting immunocompromised patients. Risk factors for severe fusariosis include prolonged neutropenia and T-cell immunodeficiency, especially in hematopoietic stem cell transplant recipients with severe graft-versus-host disease. The most frequent presentation of disseminated fusariosis is a combination of characteristic cutaneous lesions and positive blood cultures, with or without lung or sinus involvement. The prognosis is poor and is determined largely by degree of immunosuppression and extent of infection, with virtually a 100% death rate among persistently neutropenic patients with disseminated disease. These infections may be clinically suspected on the basis of a constellation of clinical and laboratory findings, which should lead to prompt therapy. Treatment options include the lipid formulations of amphotericin B, voriconazole, and posaconazole. Prevention of fusarial infection among high-risk patients should be considered.

 

It’s funny how the PubMed study only mentions pharmaceutical options when chlorine dioxide is used in water treatment facilities to eliminate Fusarium and other pathogens to make it safe for human consumption. Another odditity is that ZEA and Fusarium are virtually non-existent on health websites and Facebook mold groups. There doesn’t seem to be any related collective knowledge or experience.

If I do have Fusariosis, where would it be hiding? I’d guess in my sinuses or gut. I haven’t seen Fusarium in my live blood microscopy though I do see what I beleive is Candida (also an immunosuppresant). If it isn’t in my body, it’s probably in my plumbing drains – this has been studied and it’s a common source of infection in hospitals.

Here’s what my MD has to say about all this (with my comments after the ->):

  1. Get your home inspected for mold! -> She’s been asking me to do it for years… here’s her mold-handout (click to download).
  2. Lycopene dosing: 100 mg / day is a good dose.
  3. Reservatrol: she likes Thorne’s Reservacel for it’s Nicotinamide riboside (NR) which supports the multiple functions of cellular mitochondria.
  4. Take modified citrus pectin (MCP) because it’s the only substance known to detox glyphosate which is an immune deregulator and neurotoxin. -> I’ve restarted.
  5. Increase your grapeseed extract up to 500 mg twice a day (go slow). This is an immune booster.
  6. Add clay or chitosan, it’s not only ZEA,the other results on your test are also significant. -> I chose clay because I’ve used it before and it seems chitosan is a sugar. Her toxic binders handout is on the right.toxin binders comparison
  7. Charcoal and cholestyramine are very similar – you don’t need both of them. -> I had some sugar-free cholestyramine compounded and will leave it on the shelf for a rainy day.
  8. Start titrating an herbal antifungal because yes, you’re probably colonized by mold. -> She gave me MYCOREGEN by Beyond Balance with these dosing instructions (this is her secret sauce and deserves it’s own post) not to be confused with her medication challenge instructions.
  9. Diet: the only safe meats are buffalo, pork and wild salmon. Eggs are fine but chicken and beef are bad for fungal problems.
  10. Switch to a mold toxin tested coffee. -> I bought the 5 pound bag from Bullet Proof.
  11. Repeat the urine mycotoxin test in one year.
  12. See you in 2 months.

 

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12 thoughts to “Zearalenone and fusariosis?”

  1. I guess you induced these fungal infection with your excessive zinc supplementation. So there is probably low copper in your intestines because it’s all blocked by the zinc. With too much zinc you will also get excessive stomach acid and leaky gut (need copper for the connective tissue of the villi).

    Copper is an antimicrobial and antifungal.

    https://www.ncbi.nlm.nih.gov/pubmed/19943884

    It’s also counter-intuitive that you removed all the high-copper foods that you intuitively craved.

    I think I have the same issue with high bio-unavailable copper (II) and low bio-available copper (I).

    It’s paradox but you need copper (I) to detox copper (II). Copper is needed to produce ATP, and without ATP you can take all detox supplements in the world and it won’t help. It’s like you repair every part of an engine but it doesn’t run because you have no gas.

    1. Thanks Carvaggio, in addition to copper toxicity/deficiency, I have a lot of reasons for having fungal infection – low MSH and many different immunotoxic and suprresive problems: borrelia, candida, mercury/lead, viral load and of course the mold exposure and toxicity. I do take copper I and am titrating up… let’s add low sunshine exposure to the list!

  2. i have lived here for 20 of the past 24 months. i played quantum brady to jack’s quantum bellichik. dr bat shit crazy was 100% correct. the summer is the key. uv13 leveraged by the crater. started making my own energy from photosynthesis and making my own ddw. wild. i look back at the days of Freddd and cutler with dismay. what a fucking waste of time and money and needless suffering. 🙂 this is the real cure

    1. wow, that’s fabulous Lloyd! did you ever take enough vitamin D to get your levels way up during your CFS years? where were you living prior?

  3. i have watched you suffer for what seems like a decade now. time to go all in with kruse. i cured 35 yrsof cfs/fibro by going to the yucatan and sitting in the water. healthy mitos will fix all the crap you and I have been fucking around with since Carter was president!!! :)the sun and the chicxulub crater will detox you better than all the pills the functinal docs can throw at you. and you will save tons of $$$$$$$$$.

  4. Eric sorry I was wrong! I didn’t read the info on their website exactly…. it’s 50 $ for the test + 50 $ extra + shipping. I think the 150$ of your doctor are the approximate costs. Sorry again. You can delete my first massage if you want.

  5. Sorry to hear that the test came back positive 🙁

    I am exposed to toxic mold from the crawling base in my house for 6 years and I am pretty sure it’s in my body.

    People advice to follow the Shoemaker protocol:
    1. Cholestyramine and Welchol to bind to the mycotoxins in the intestines, and pull them out of the body.
    2. The no amylose diet.
    3. The antibiotic BEG nasal spray to get rid of a MARCoN infection in the nasal and sinus mucous membranes

    Are you known with the Shoemaker protocol?

    1. Hi Johan, thanks and yes familiar with Shoemaker… I do follow the mold diet and have taken cholesytramine. Will take it again but I suspect coffee enemas may be more effective at stopping bile recycling. Klinghardt and others are now saying probiotics work better for the sinus infections.

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