Understanding potassium

Anyone following Freddd’s methylation protocol or any other high dose methylation support should know there’s a risk of creating a potassium deficiency which is potentially lethal. It’s called hypokalemia. Muscle cramping is one of the warning signs and I’ve experienced some of those cramps. I’m currently supplementing with 2.2 g of elemental potassium a day and suspect I still need more, so I’m trying to understand the potassium issue in more depth before taking more potassium.

It’s a complicated subject because both too little and too much potassium is dangerous. For this reason, Andy Cutler recommends you not exceed 1 g of supplemental potassium without “doctor supervision”. While I appreciate the warning and take it seriously, I’m saving this precious oxymoron ‘doctor supervision’ as the title for a new post about my pathetic experience with doctors.

The more I learn, the more I think potassium may be one of those cornerstone supplements for me and for many others. Most of the information on this page comes from Stephanie’s posts on FDC who just happens to be studying and experimenting at the same time as I am:

These observations are all from the book “Potassium Nutrition” ($4 kindle book on Amazon) unless otherwise noted – the author explores all the research relating to dietary potassium deficiency leading to a functional deficiency, and how it applies to many chronic disease processes (he essentially includes chronic fatigue and fibromyalgia as well). In some cases these correlations have not been examined before, in part because conventional medicine overlooks the role of potassium, and the labs that are typically used to assess potassium and electrolyte levels don’t give the entire picture.

There really isn’t a good way to assess the overall level of our potassium status (it is possible but the tests to determine this aren’t really available – it requires special equipment which is very expensive). Even measuring RBC potassium and sodium doesn’t give the complete picture – for one thing, our bodies will lose potassium from muscle cells at a far greater rate than blood cells- and this is why muscle cramps and weakness are common symptoms.

Potassium gluconate (one of the most available supplement forms) goes into solution easily to give potassium ions (which is the electrolyte), and the gluconate part is metabolized in the liver to create bicarbonates. Bicarbonates are also electrolytes. So this is similar to supplementing potassium bicarbonate.

Potassium bicarbonate is alkalizing and it helps to prevent calcium loss that can be caused by a functional potassium deficiency…. which are both desirable for most people – particularly given modern diets. Potassium bicarbonate is also the form most similar to what you get from eating vegetables. However potassium bicarbonate will tend to lower blood pressure.

My sense is that salt cravings are a way to help raise blood pressure – it’s actually the chloride in salt that tastes salty and raises blood pressure. My blood pressure was definitely getting lower after cutting back hugely on salt and supplementing with potassium bicarbonate over the course of a few days. Note that one teaspoon of potassium bicarbonate contains roughly 2000 mg of potassium.

If you have low blood pressure, it’s preferable to supplement primarily with potassium chloride – and use potassium bicarbonate (or potassium gluconate) to help balance pH (if urine pH becomes acidic). Too much bicarb will be too alkalizing and will lower blood pressure so it needs to be balanced with the chloride – which does the opposite.

Chloride is another important electrolyte – it gives the salty taste to salt and tends to raise blood pressure (loss of chloride usually accompanies a potassium deficiency because chloride is secreted to maintain serum pH). So naturally, potassium chloride tends to raise blood pressure, and tends to be acid forming. Potassium chloride will also help to raise the cell levels of potassium faster than potassium bicarbonate. This seems to make sense given their relative effects on electrolyte balance and blood pressure and pH.

An ideal ratio of total daily intake (diet and supplements) of potassium to sodium is said to be something like 5:1. But, a low potassium to sodium ratio is the norm these days – especially if you compare that to the ratio that researchers believe humans evolved on… potassium sources were plentiful and the mainstay of diet, whereas sodium was very scarce. Paleo man probably had at least a 10:1 potassium to sodium ratio in his diet, and many put that estimate much higher. So even people who eat a relatively healthy diet these days aren’t necessarily immune to the effects of a lower ratio – given the availability of sodium, and the relative scarcity of high potassium foods from plant sources…, together with all the other influences that affect our acid-alkaline balance and electrolyte balance in modern life (i.e. toxicities).

Now, even getting to a ratio of 2:1 or 3:1 is better than the average human who eats a lot of processed foods. Of course, there are many other factors besides this ratio to consider – including the source of potassium in food and whether it forms bicarbonates and is therefore alkalizing (this would be the potassium from plant sources, especially leafy greens) – or whether it makes chloride and is therefore acidifying (from protein sources of potassium), so this relates to our pH balance.

If a person is very deficient (at the cell level), then it can take a long time for general healing to occur… maybe 6 months to a year or more. However, if you’re supplementing – say 1 gram with each meal (~3 grams/day) – then you should be able to correct the deficiency state in a matter of weeks, assuming you lower sodium appreciably and otherwise eat a decent diet and you’re getting enough magnesium, taurine etc (according to Wikipedia, “In cells, taurine keeps potassium and magnesium inside the cell, while keeping excessive sodium out” so, supplementing with taurine – up to 3 grams per day – may be helpful).

Medications, and other things that might cause potassium loss or create acidity (like toxicity from metals and chelating) have to be taken into account as to how much potassium is right for you, and whether you need extra bicarbonate to neutralize acidity. It’s ideal to get our potassium from food of course, but it seems that can be kind of hard to do, especially for someone dealing with toxicities.

Hence, supplementing with potassium chloride and potassium bicarbonate as indicated can help improve our K to Na ratio, and overcome the effects of “poor” dietary influences, medications, toxins etc. It’s worth considering that the author of this book suggests that, “our bodies don’t store potassium”…but we need to continually take in a lot of it for healthy metabolism, nerve function etc.

What becomes pertinent is our ability to regulate the level of potassium in serum and in cells… Which leads to the topic of aldosterone – which is essential for regulating serum potassium… The question being, is it possible one might be low in aldosterone at least in part because we are functionally deficient in potassium? And will slowly improving this ratio of K to Na allow our aldosterone levels to rise along with potassium intake?

The info in this book suggests this is generally this case (short of permanent atrophy of the part of the adrenal gland that produces aldosterone – or I suppose secondary adrenal insufficiency will prevent the appropriate signaling for the release of adrenal hormones, no matter how much potassium is available). Regardless, one shouldn’t drastically increase potassium intake without keeping an eye on our serum potassium to ensure that our body is handling it properly – as Andy has told us.

If we don’t have adequate aldosterone, we can go high on serum potassium… And there are other factors too, certain medications and kidney function factor in. By the way, the same could apply to cortisol – that is, secretion may rise as potassium is increased.

Increasing methylation may have the effect of pulling more potassium into cells that are deficient… at the expense of serum potassium – causing low serum potassium (this is Rich Van K’s theory). According to this theory, people with chronic fatigue caused by methylation block have fewer cells than normal. Ramping up their methylation cycle supplies the missing folate needed to make new DNA and suddenly the body can make new cells. This is what we call ‘healing’:

All of a sudden, the cells now have enough DNA to overcome the arrest of the cell cycle, and their rate of cell division goes up, making new cells more rapidly. These new cells require potassium, and their membrane pumps start pumping it in from the blood plasma. Unfortunately, since the existing cells, which contain 95% of the body’s potassium inventory, are already low in potassium, there is no cushion or buffer for the blood plasma potassium level, and if it is not augmented by increased potassium intake from the diet or supplements, the PWC’s blood plasma potassium level drops, resulting in hypokalemia.

While both the cell and serum levels of potassium are important, it’s the serum level of that can be very dangerous if it goes out of the so-called “normal” range. So, if you are ramping up your methylation cycle, keep a bottle of potassium around and know the symptoms of hypokalemia (weakness, lack of energy, muscle cramps, stomach disturbances, an irregular heartbeat, and an abnormal EKG) and hyperkalemia (muscle weakness, slowed heart rate, and abnormal heart rhythm).

A few words from the author himself, Charles Weber, MS. We asked the author of Potassium Nutrition, to review the summary above for accuracy and this is his response:

I did not see anything in the URL you sent that was obviously invalid. The body is a complicated soup, though, and it is easy to get things wrong. If a person’s kidneys have not been damaged, by poison for instance, that person can do some great nutritional blunders with respect to potassium and still stagger through. Healthy kidneys can handle some bizarre ratios since they have much more capacity than they need. The only circumstance that I know of that is desperately dangerous is the interaction between potassium and thiamin (vitamin B-1). If potassium is supplemented it is essential that vitamin B-1 be adequate (see http://charles_w.tripod.com/kandthiamin.html ). And of course, if the kidneys have been damaged in such a way as to be unable to excrete potassium there is some danger from supplements. This can easily determined by blood analysis.

 

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77 comments…
  • avatar

    Pabu September 15, 2016, 1:27 pm

    Dear Eric,

    I am following Dr. Yasko methylation protocol, and I am double MTRR A66G (+/+) , VDR taq (+/+) and CBS C667T (+/-), and BHMT (+/-) Based on my hair mineral test, I am dumping mercury. In March, my mercury levels were in 95 percentile, and in august my mercury level dropped to 68 percentile. I can’t eat sulphur foods without liver pain. I can’t eat animal protein because of glutamate hyper anxiety effect. So, i just eat pumpkin protein and some lentils, i am aware it is thiol given the mercury issue. My doctor told me i am extremely protein deficient including sulphur amino acids, which explains why my muscle were wasting away. The supplements I take are trace mineral complex, small molybeum (for sulphur), B12 spray (hydro and adenosyl cobalamin), Liposomal Vitamin C, Active form of B complex, DHA, and probiotics . I believe i am under methylator based on my symptoms from years and years of suffering. The biggest problem i have is that my liver/spleen is swollen, and sulphur issue does not help. Sometimes the probiotic really helps to break down the sulphur bubbles. I just started the Dr. Yasko protocol and she recommended special B12 spray based on my hair mineral test and genetics. B12 does make me feel like a normal person in ages, and i have been on it for 2 weeks the most. At one time, my potassium and lithium was very low. So, i took some potassium and lithium before starting the B12. My potassium has normalized and my lithium levels went thru the roof, and it made me very ill, and disattached from the world.I no longer take lithium supplement because the levels were too high from small dose for one month, and it made me feel awful. What is your intake of lithium in connection to B12. I know Dr. Yasko says that one needs lithium mineral to transport B12 into the cells. How can you keep lithium levels normal without supplementing because lithium just makes me feel awful. Plus, i have to keep an eye on my potassium. In addition, do you think in time B12 will help to reduce the swollen painful liver/spleen in time? What are your thoughts?

    Reply
    • avatar

      Eric September 15, 2016, 4:36 pm

      Every time I have tried to take 5 mg of lithium I have felt drowsy and brain fogged, so I have not solved this problem. But one of my blog readers said that by drinking Pellegrino, She got just the right amount. It does have some fluoride in it which could be harmful but she says it is just the natural amount of fluoride found in the water, that it is not added… have you thought about doing some liver flushes?

      Reply
      • avatar

        Pabu September 15, 2016, 7:27 pm

        Hi Eric,

        I am been doing dandelion, milk thistle, and artichoke extract for three years now plus fresh lemon water daily. I also drink beets juice with fresh ginger daily.

        I got a big sulphur problem, and since starting the B12, my liver symptoms seems to even flare up more. Perhaps, i have to go thru a storm before i see a rainbow. Can starting b12 protocol flare up digestive issues? Could B12 cause a inflammation response or detox? I wake up every morning around 4 am with extreme hunger and sometimes without hunger and never get back to sleep. This is going on forever. I am really sensitive individual and responded fairly quick to even the tiniest amount of supplement.

        Reply
        • avatar

          Eric September 17, 2016, 3:16 pm

          Yes I believe you can experience a detox from B12 and what some call startup reactions. Did you read the active B12 post here on my blog? Please note also that vitamin B12 can feed a fungal infection…

          Reply
      • avatar

        Pabu September 15, 2016, 11:34 pm

        On regards to Lithium, did you try cutting the capsule of lithium rotate in 1/2 or 1/4 or not everyday. I even tried the drops, but the side effects were so severe, I had to quit taking it. I already have difficult sleeping, and staying asleep, lithium added to the problem. Perhaps, I will try the Pellegrino water. I also read that pistachio nuts and legumes have high traces of lithium. Did you try that route? Thank you so much Eric for the information.

        Reply
        • avatar

          Eric September 17, 2016, 3:14 pm

          I never tried dividing the capsule Pabu but now I think I should!

          Reply

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what we need to know.
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-Pema Chodron

"God, whose law it is that all who learn must suffer. And even in our sleep pain that cannot forget, falls drop by drop upon the heart, and in our own despair, against our will, comes wisdom to us by the awful grace of God."
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My name is Eric - I‘m 46 and saw a doctor for fatigue at 17. I lived fairly normally if a little subdued by lack of endurance at times. But then, 12 years ago I fell into a nosedive after moving to South Florida. Now, I know heavy metal toxicity is a significant source of my troubles along with genetic methylation cycle dysfunction. I spent 18 months chelating the metals out and starting up methylation but stopped when I felt myself circling the drain. Currently doing liver, colon, kidney and parasite cleanses. More about me here.

Timeline and current dosing:

Rounds completed: 29
Total chelation days: 125
Dose: 25 mg DMSA and 25 mg ALA every 3 hrs

* supplements
* hair test
* genetics
* lessons learned

"Battles are won in their darkest hours. Wars are won by learning something from each battle."
-Eric

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