The supplements

chelation-supplementsNote, I have been taking many of the supplements you see here for a year or more. in most cases I started with smaller quantities and worked my way up. It’s especially important to do that with chelators and methylation supplements. Be careful! Never make decisions about dosing based on what’s easiest – either split capsules or tablets or order the right dose. You can get small increment doses of chelators from Livingnetwork.

I’m trying to reduce the number of supplements I take and anything I’m no longer taking you’ll see in strike-through format. As much as possible, my aim is to use food instead of supplements!

  1. Amino acids
  2. Antioxidants and fatty acids
  3. B vitamins
  4. Chelators, detox etc
  5. Hormonal and pharmaceutical
  6. Herbal & other
  7. Minerals and elements
  8. To try

Amino acids

  • Arginine – 6 g (added 5/24/13) – Arginine plays an important role in cell division, the healing of wounds, removing ammonia from the body, immune function, and the release of hormones. The benefits and functions attributed to oral supplementation of L-arginine include: 1) Precursor for the synthesis of nitric oxide (NO), 2) Reduces healing time of injuries by stimulating growth hormone release (particularly bone), 3) Quickens repair time of damaged tissue, and 4) Helps decrease blood pressure in clinical hypertensive subjects. Arginine is synthesized from citrulline by the sequential action of the cytosolic enzymes argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL). In terms of energy, this is costly, as the synthesis of each molecule of argininosuccinate requires hydrolysis of adenosine triphosphate (ATP) to adenosine monophosphate (AMP), i.e., two ATP equivalents. In essence, taking an excess of arginine gives more energy by saving ATPs that can be used elsewhere.
  • Carnitine fumarate – 2 g (added 5/30/13, take 30 min before meals) – Carnitine is a quaternary ammonium compound biosynthesized from the amino acids lysine and methionine. In living cells, it is required for the transport of fatty acids from the intermembraneous space in the mitochondria, into the mitochondrial matrix during the breakdown of lipids (fats) for the generation of metabolic energy. Your body makes it in the liver and kidneys and stores it in the skeletal muscles, heart, brain, and sperm. Usually, your body can make all the carnitine it needs. Some people, however, may not have enough carnitine because their bodies cannot make enough or can’t transport it into tissues so it can be used. Carnitine has been proposed as a treatment for many conditions because it acts as an antioxidant.
  • L-Citrullinerestores nitric oxide production which declines normally with age.
  • Lysine – 2 g (added 5/25/13) – Lysine is important for proper growth, and it plays an essential role in the production of carnitine, a nutrient responsible for converting fatty acids into energy and helping to lower cholesterol. Lysine appears to help the body absorb calcium, and it plays an important role in the formation of collagen, a substance important for bones and connective tissues including skin, tendon, and cartilage. According to Dr. Cutler, lysine also improves concentration ability and helps stimulate growth hormone release in combination with arginine.
  • Taurine500 mg 1 x day – increases the action of insulin, improving glucose tolerance, and acts as an antioxidant, vital for the proper function of the minerals potassium, calcium, magnesium, and sodium. Taurine regulates heart rhythm, cardiac contraction, blood pressure, and platelet aggregation, and regulates the excitability of neurons. It detoxifies liver cells of various toxins. It helps form bile acids and maintains cell membrane stability. It reduces the synthesis of lipids and cholesterol that are associated with atherosclerosis. Protects against toxicity of various substances (such as lead and cadmium). Additionally, supplementation with taurine has been shown to prevent oxidative stress induced by exercise. In cells, taurine keeps potassium and magnesium inside the cell, while keeping excessive sodium out. In this sense, it works like a diuretic. Make sure you don’t have the CBS upregulation before taking taurine.

Antioxidants and fatty acids

  • Vitamin A, 10,000 IU 2 x day – made from beta-carotene in the liver. Dr. Cutler recommends supplementing on the basis that mercury may be interfering with production of the active form in the liver. Conversion of beta-carotene to vitamin A is also inadequate if hypothyroid. May help with skin conditions including psoriasis. Most of the vitamin A varieties I found online come from large fish prone to mercury accumulation. I get one made from Atlantic cod which is lower on the mercury lists. Also listed on Freddd’s methylation protocol and the Pfeiffer treatment center copper detox protocol.
  • Raw Vitamin C – 500mg – gives me insomnia if I’m not careful – supports the adrenal glands and has for years been the one supplement that I can easily feel the benefit from within minutes of taking. I’ve also had intravenous vitamin C up to 50 g and generally believe the miracle-cure stories I’ve read about in The Clinical Guide to the Use of Vitamin C by Dr. Klenner. Vitamin C is on Dr. Cutler’s essential list, companion nutrients for iodine and Freddd’s methylation protocol. Also on the Pfeiffer treatment center copper detox protocol. Many laboratory studies have been done to find out how high-dose vitamin C may cause the death of cancer cells. The anticancer effect of vitamin C in different types of cancer cells involves a chemical reaction that makes hydrogen peroxide, which may kill cancer cells. Vitamin C interacts with iron and other metals to create hydrogen peroxide. In high concentrations, hydrogen peroxide damages the DNA and mitochondria of cancer cells, shuts down their energy supply, and kills them outright. Best of all—and unlike virtually all conventional chemotherapy drugs that destroy cancer cells—it is selectively toxic. No matter how high the concentration, vitamin C does not harm healthy cells.
  • E Complex – 3 x day – According to Dr. Cutler, vitamin E protects the essential fatty acids and your cell membranes which are particularly vulnerable to mercury. Vitamin E is on Dr. Cutler’s essential list and Freddd’s methylation protocol. Also on the Pfeiffer treatment center copper detox protocol. At one point, the NOW variety I use was recommended by Freddd.
  • Evening primrose oil – 500 mg – a source of gamma linoleic acid (GLA), and Omega six essential fatty acid, used in the production of prostaglandins for limiting and controlling inflammation allergic response etc (Cutler). Initially, I used Borage oil, but found it gave me an upset stomach, possibly because the gel caps were much larger. The NOW brand comes in small or 500 mg softgels. Evening Primrose oil is apparently good for eczema and detoxes .
  • Cod Liver Oil –  (used to give me insomnia at normal recommended amounts) – Dr. Cutler says Mercury destroys EFA’s and the brain is especially high in EFA’s so therefore especially affected. Low EFAs can affect your energy level – reading this was an epiphany for me. In AI, Cutler only recommends fish oil for the first month or two of supplementation and then says that you will start making EPA and DHA from flax oil after a month or two. Based on the numbers shown here you would be getting much less DHA using Flax than you typically would from fish oil… Omega 3 oil has been shown to improve lymphatic flow and that’s critical for people like me with multiple infections and toxicities! Fish oil is also listed as critical for basic healing on Freddd’s methylation protocol. CLO is a staple of The Root Cause Protocol which I follow as a source of Vitamin A. But I’m rather convinced by Brian Peskin and Dr. Robert Rowen’s take on the matter and have switched over to this EFA supplement.
  • Essential Fatty Acids – 2100 mg – recommended by by Brian Peskin and Dr. Robert Rowen
  • Sunflower Lecithin 1.2 g = 210 mg phosphatidylcholine – taken for its phosphatidylcholine and phosphatidylserine content. I eat eggs for choline too. According to Dr. Cutler “phosphatidylcholine is used to make cell membranes which is the part of the body Mercury beats up the most and is used to make the neurotransmitter acetylcholine in the brain . . . Phosphatidylserine helps make better brain cell membranes. It is a good antidepressant and brain tonic – much more effective than phosphatidylcholine and lecithin.” Also recommended by Rich Van K as part of his Simplified Methylation Protocol. From NIH: Humans ingest approximately 50 mmol of methyl groups per day; 60% of them are derived from choline. Transmethylation metabolic pathways closely interconnect choline, methionine, methyltetrahydrofolate (methyl-THF) and vitamins B-6 and B-12.

B vitamins

  • B-1 / thiamine – 150 mg benfotiamine – B-1 helps the liver process whatever doesn’t belong in your body. The brain requires a much greater amount of thiamine than in other cells of the body. Of special interest to me is Dr. Cutler’s statement “allows people […] who are very sensitive to choline precursors like DMAE to use more of them.” This has something to do with B-1’s ability to block the M1 acetylcholine receptor. Although I don’t understand what this is all about, my attention is drawn because I don’t tolerate phosphatidylcholine or omega-3 well and I have a touch of MCS. Omega-3 is known to boost acetylcholine levels, so my hypothesis is that it could be an increases in acetylcholine which cause my insomnia. Therefore, maybe vitamin B1 can help me tolerate more fish oil. In any case, in HTI, Dr. Cutler mentions that “arsenic interferes with the utilization of vitamin B1, with the production of acetylcholine and with the transfer of pyruvate into the mitochondria. Reduced thiamine utilization impairs the conversion of food into energy and leads to fatigue, poor healing and impaired thinking.” There’s also a chance that supplementing thiamine may aid cadmium chelation. So for all these reasons, I’m going to keep supplementing vitamin B1 and I’ve decided to switch over to the active form, Benfotiamine and have ordered this. Note, some people have found that high doses (1800 mg) of thiamine can reverse chronic fatigue. NOTE: thiamine is depleted by B-6 and ALA and antagonists include quercetin and rutin. The SLC19A1 gene encodes a transporter involved in folate and thiamine uptake, so anyone with flaws on this gene and potentially other similar genes who takes a lot of folate might find that the folate competes with thiamine causing a deficiency.
  • B-2 / riboflavin – 150 mg – plays a key role in energy metabolism and metabolism of fats, carbohydrates and proteins. According to Dr. Cutler, it is absorbed better in divided doses (he recommends 50 to 100 mg total). Seems to be very effective for migraines and is the vitamin that gives B complex preparations their yellow color, and makes your urine florescent yellow. The name “riboflavin” comes from “ribose” (the sugar whose reduced form, ribitol, forms part of its structure) – that caught my eye because I also use D-Ribose before and after exercising on Freddd’s recommendation. May accelerate methylation causing insatiable hypokalemia according to Freddd.
  • B-3 / niacin – 300 mg – reading about niacin is very confusing so you might want to start with something simplistic like the University of Maryland page before moving on to AI or Wikipedia. I take niacin because it is a companion supplement for iodine (says to avoid niacinimide) and I like the fact that it’s involved in DNA repair and adrenal function. It also quenches methylation by using up methyl groups (use regular niacin for this if you get overstimulated on methylation supports). It speeds up phase I metabolism and increases brain circulation. Lowers copper levels too.  It also acts as an antibiotic against Borrelia according to Dr. Klinghardt. Here’s some interesting info about the Niacin flush effect and it’s role in the sauna detox protocol.
  • B-5 / pantethenic acid – 500 mg x 2  – considered the more biologically active form of vitamin B5. Supports the liver and adrenal function. Also used in the synthesis of CoA which plays a role in the Krebs cycle and synthesis of fatty acids, cholesterol and acetylcholine. Also on the Pfeiffer treatment center copper detox protocol.
  • Pantethine450mg x3 – Recommended for anti retroviral support by Dr. Klinghardt.
    And for autoimmune problems, Dr. Atkins states, ” For all conditions that a doctor might prescribe prednisone — allergies, asthma, rheumatoid arthritis, psoriasis, lupus, and olther autoimmune diseases, pantethine can be safely, effectively substituted. I routinely use it for all of those conditions on hundreds of my patients, and it’s valuable in weaning them off steroidal drugs, or certainly in allowing a lower dose…. By upping body levels of a body enzyme, pantethine counteracts brain fog, certain allergic sensitivities, and some consequences of alcoholism. . . In people with candidiasis, the enzyme fights off a toxic byproduct called acetaldehyde, which is thought to cause brain fog, often-suffered but rarely diagnosed…. Acetaldehyde also is suspected of being responsible for some symptoms of alcoholism, including alcoholic heart muscle disease. The pantethine-stimulated enzyme also detoxifies formaldehyde, an all too frequent offender for chemically sensitive individuals.” For Candida, Dr. Cooter and Dr. Schmtt suggest 300 micrograms of Molybdenum in three divided doses per day, and further suggests staying on it for at least 4 months.. Dr. Atkins suggests 450 to 900 miligrams daily of Pantethine with an equal amount of Pantethenic Acid.
  • B-6 – 100 mg (added when hair test showed essential element ratios indicate need for more B6) – According to Dr. Cutler, mercury causes chronic fatigue by interfering with brain uptake of vitamin B-6 and B12. It sits solidly on the methylation map: 1) amino acid metabolism – critical for trans-sulfuration (p5p is a coenzyme needed for the proper function of the enzymes cystathionine synthase and cystathionase which work to transform methionine into cysteine) and transamination including creating serotonin from tryptophan, GABA from glutamate and dopamine from dihyroxyphenylalanine, 2) gluconeogenesis – catalyzes reactions essential for providing amino acids used as substrates for gluconeogenesis, is a required coenzyme of glycogen phosphorylase, the enzyme necessary for breakdown of glycogen to glucose to occur in muscle and liver tissue and 3) lipid metabolism – an essential component of enzymes that facilitate synthesis of sphingolipids which have particular impact on neural tissue and 4) metabolic function – involved in histamine synthesis, hemoglobin synthesis and function and gene expression. Also on the Pfeiffer treatment center copper detox protocol.
  • B-7 / biotin – 10,000 mcg – In HTI, Dr. Cutler notes that biotin opposes the toxic effects of thallium and suggest taking 5 to 10 mg with meals and at bedtime. My urine challenge test showed moderate thallium. Oddly, my hair test showed none. Biotin is a co-enzyme for carboxylase enzymes involved in the synthesis of fatty acids, cholesterol and gluconeogenesis. From the Linus Pauling Institute: “Reductions in blood glucose levels were found in seven insulin-dependent (type 1) diabetics after one week of supplementation with 16,000 mcg of biotin daily (28). Several mechanisms could explain a possible blood glucose-lowering effect of biotin. As a cofactor of enzymes required for fatty acid synthesis, biotin may increase the utilization of glucose for fat synthesis. Biotin has been found to stimulate glucokinase, a liver enzyme that increases synthesis of glycogen, the storage form of glucose. Biotin has also been found to stimulate the secretion of insulin in the pancreas of rats, which also has the effect of lowering blood glucose (29).” It is also almost universally recommended supplement for Candida, but perhaps mistakenly so.
  • B-9 / folate – 7.5 mg – folate plays a significant role in the methylation cycle, and in AI, Dr. Cutler recommends 1.6 to 10 mg saying that “folate is generally safe and helpful and most people benefit from 3 mg per day”. I use the active form from NOW because some people don’t convert well from folic acid. As one FDC member put it “I wasted years of better health by not trying methylfolate sooner when I had the chance. When a doctor suggested I try Folapro several years ago, I dismissed it as a fad and erroneously thought that I was fine taking 2400 mcg of regular folate a day.” One of the functions of methylfolate is to increase absorption and retention in the body of both adb12 and mb12. Best if taken twice a day. Note, that many people are very sensitive to folate and can have strong start up reactions which may include anxiety, jitters, lightheadedness, fatigue, headache etc. May deplete vitamin B-1 (see B-1 above).
  • B-12 / methylcobalamin – 2.5 mg (when I reached 5 mg with 3.2 mg folate the first time around, I had a strong reaction, so I’m titrating up again from a much lower starting point) – also called cobalamin, plays a key role in the methylation cycle and normal functioning of the brain and nervous system, and the formation of blood. It is involved in the metabolism of every cell of the human body, especially affecting DNA synthesis and regulation, but also fatty acid synthesis and energy production. B12 deficiency symptoms are wide ranging and serious enough to destroy your life but healing begins within minutes of supplementing. Best taken sublingually under the upper lip several times a day (brand matters with this one – I’m using Enzymatic Therapy and Jarrow is okay too).
  • B-12 / dibencozide – 2 mg – one of the active forms of vitamin B12, also known as cobamamide, adenosylcobalamin or adb12, it generally has much milder and fewer startup reactions. Said to populate the neural mitochondria, energizing the central nervous system in a very pleasant way, improving mood and clarity of thought. Forms part of the Krebs cycle for production of energy. Best taken once a day early in the morning to avoid interference with sleep.

Chelators, detox etc

  • IP6Phytic acid—also called inositol hexaphosphate, or IP6—is comprised of six phosphorus molecules and one molecule of inositol. In foods, phytic acid binds to iron and other minerals in the digestive tract and may interfere with mineral absorption. As a purified extract of rice bran, taken between meals so it will not bind to minerals in the digestive tract, phytic acid is readily absorbed into the bloodstream, where it acts as a potent mineral chelator. Phytic acid binds to any free iron or other minerals (even heavy metals such as mercury, lead and cadmium) in the blood, which are then eliminated through the kidneys. Phytic acid removes only excess or unbound minerals, not mineral ions already attached to proteins. Phytic acid is such a potent—but safe—iron and mineral chelator that it may someday replace intravenous chelation therapy such as the mineral-chelator EDTA or iron-binding drugs such as desferrioxamine (Desferal). Because of its ability to bind to iron and block iron-driven hydroxyl radical generation (water-based) as well as suppress lipid peroxidation (fat-based), phytic acid has been used successfully as an antioxidant food preservative.
  • Kelp – from New Zealand as a substitute for Iodine – I sprinkle it on salads.
  • lactoferrin-reviewLactoferrin – Lactoferrin’s primary role is to sequester free iron, and in doing so remove essential substrate required for bacterial growth. Antibacterial action of lactoferrin is also explained by the presence of specific receptors on the cell surface of microorganisms. Lactoferrin binds to lipopolysaccharide of bacterial walls, and the oxidized iron part of the lactoferrin oxidizes bacteria via formation of peroxides. This affects the membrane permeability and results in the cell breakdown (lysis).An iron-binding protein analogous to the iron transporter transferrin; it binds and sequesters iron in areas outside of the bloodstream such as the mucous membranes, gastrointestinal tract, and reproductive tissues (Jiang 2011). It is present at high concentrations in milk, and is secreted by immune cells (neutrophils) as an antibacterial compound at sites of infection or inflammation (Paesano 2009; Brock 2012).Each lactoferrin molecule can reversibly bind two ions of iron, zinc, copper or other metals. It is demonstrated that lactoferrin is involved not only in the transport of iron, zinc and copper, but also in the regulation of their intake. Presence of loose ions of zinc and copper does not affect the iron binding ability of lactoferrin, and might even increase it.
  • Rutin – 500 mg – Polyphenols such as chlorogenic acid (Kono 1998), quercetin, rutin, chrysin (Guo 2007), punicalagins (from pomegranate) (Kulkarni 2007), and proanthocyanidins (from cranberry) have been shown to bind iron in vitro (Lin 2011). In an in vitro binding study of 26 flavonoids (a type of polyphenol) isolated from a variety of sources (including tea catechins, hesperidin, naringenin, and diosmin), several were nearly as effective as desferoxamine at chelating ferrous iron when supplied at a 10:1 flavonoid/iron ratio.
  • Rice Bran – a natural iron chelator to complement or substitute for IP6.
  • Charcoal – I use activated charcoal to diminish detox symptoms and during my peak Candida detox took 60 g a day for abougt two weeks. Activated charcoal has an advantage over other gut decontamination methods because it can “catch up” to substances that have moved beyond the pylorus into the small intestine. It can bind up to 60% of a toxin when given within 30 to 60 minutes after the ingestion. Even when certain toxins have been absorbed into the bloodstream, multiple doses of activated charcoal, sometimes called “gut dialysis,” can help increase their elimination. An adult may receive 12.5 grams/hour of activated charcoal until his drug levels reach nontoxic levels, typically within 24 hours. The drug is eliminated through a process of back diffusion from the mesenteric capillaries across the GI epithelium into the GI tract, where it’s adsorbed to the charcoal. Activated charcoal has the ability to attach (adsorb) cholesterol and bile acids present in the intestine, preventing their absorption. Many people use bentonite clay for this purpose, but I’ve always been hesitant to take clay because of its aluminum content and tendency to constipate.
  • N-acetylcysteine (NAC) – 1,500 mg – recommended by Dr. Cutler in the 500 to 4,000 mg range for raising blood glutathione. He says that people who are sensitive to paint fumes exhaust or the preservatives BHT, BHA, and TBHQ and other hydrocarbons are most likely to benefit. NAC is a slightly modified version of the sulfur-containing amino acid cysteine. When taken internally, NAC replenishes intracellular levels of the natural antioxidant glutathione (GSH, often deficient with advancing age and in chronic illness), helping to restore cells’ ability to fight damage from reactive oxygen species (ROS). NAC also regulates expression of scores of genes in the pathways that link oxidative stress to inflammation. These dual effects give NAC a unique role in the prevention and treatment of many common diseases, both acute and chronic. NAC can protect against avian influenza and more common seasonal flu symptoms. NAC protects tissues from the effects of exercise-induced oxidative stress, adding value and safety to your workout. NAC improves insulin sensitivity in people with some of the most difficult-to-treat metabolic disorders. NAC blocks cancer development at virtually every step in the process, and through multiple mechanisms, making it an important cancer chemopreventive agent. One of those mechanisms involves copper and may explain why NAC may help reduce copper toxicity.
  • S acetyl glutathione – 300 mg – this form is as effective or more so than liposomal glutathione – the most important molecule you need to stay healthy and prevent aging, cancer, heart disease, dementia and more, and necessary to treat everything from autism to Alzheimer’s disease. Called the mother of all antioxidants. The good news is that your body produces its own glutathione. The bad news is that toxins from poor diet, pollution, toxins, medications, stress, trauma, aging, infections and radiation all deplete your glutathione. If you’re like me, you’ll need to work up to this amount slowly.
  • ALA (alpha lipoic acid) – binds mercury like DMSA but also has the advantage of crossing the blood brain barrier to chelate mercury from your brain (and internal organs). According to Dr. Cutler, the effectiveness of ALA with lead is unknown but may possibly remove it from the brain along with mercury. Increases liver secretion of bile, darkening and loosening stools. Like DMSA, it must be taken every 3 to 4 hours (including night doses ) for minimum of three days at a time. Also useful for chelating antimony, arsenic, palladium, platinum, thallium and possibly cadmium, tungsten, lead and silver. Apart from its properties as a chelator, Alpha-lipoic acid is an antioxidant that is made by the body and is found in every cell, where it helps turn glucose into energy (reactions involving two key enzyme complexes of the Krebs Cycle require ALA as a cofactor). Other antioxidants work only in water (such as vitamin C) or fatty tissues (such as vitamin E), but alpha-lipoic acid is both fat- and water-soluble. That means it can work throughout the body. You can expect Lipoic Acid to exacerbate the following symptoms: increased urine volume, obsessive thinking, emotional volatility, difficulty relating to people, and apathy. Your liver will excrete more inorganic mercury but less methylmercury, copper, zinc and cadmium. ALA is listed on Freddd’s methylation protocol as a possibly critical show-stopper cofactor. May deplete vitamin B-1 (see B-1 above).
  • DMPS – 3.125 mg x 3 – dimercapto-1-propanesulfonic acid is an extracellular chelating agent that cannot enter cells but binds with heavy metals in fluids surrounding cells and in the blood. It also can’t cross the blood brain barrier. Its primary use seems to be in mopping up the mercury that is freed by the use of ALA. Dr. Cutler says it suppresses symptoms very well and recommends using on an eight hour schedule which makes it much easier to use than DMSA. According to Dr. Cutler, orally administered DMPS relieves symptoms more promptly and completely than DMSA and is often tolerated better. He says too that DMPS increases the excretion of mercury in the urine but not in the feces. As for the metals DMPS will chelate, there is some disagreement between author David Hammond who recommends it for removing mercury, arsenic, lead, antimony and copper, and Dr. Cutler who calls it a chelator for mercury and arsenic.
  • DMSA (dimercaptosuccinic acid) – binds lead and mercury to remove it from your body (but does not cross the blood brain barrier). With a half-life of 2 1/2 to 3 1/2 hours it should be taken at least every four hours (including night doses) for at least three days at a time. May aggravate or cause neutropenia according to Dr. Cutler. Causes heavy oxidative stress, so very important to take antioxidants while chelating. Also effective for chelating antimony, bismuth, cadmium, thallium, and possibly nickel, tungsten, palladium, platinum, silver, gold and arsenic.

Hormonal & Pharmaceutical

  • Hydrocortisone – I’m down to 10 mg from 30. Discovered this is a key risk factor for Candida infection as HC feeds it.
  • Fenbendazole – 150 mg – fenben is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites including: giardia, roundworms,hookworms, whipworms, the Taenia genus of tapeworms(but not effective against Dipylidium caninum, a common dog tapeworm), pinworms, aelurostrongylus,paragonimiasis, strongyles and strongyloides and can be administered to sheep, cattle, horses, fish, dogs, cats,rabbits and seals. In theory, via FtsZ binding, may also disrupt ecoli, lyme, malaria, toxoplasmosis, fungi, virus, syphilis etc.
  • DHEA – 15 mg – the most common hormone precursor in the body, is intimately associated with youthful and healthy functioning across a range of physiological systems. Used for slowing or reversing aging, improving thinking skills in older people, and slowing the progress of Alzheimer’s disease. Athletes and other people use DHEA to increase muscle mass, strength, and energy. But DHEA use is banned by the National Collegiate Athletic Association (NCAA). DHEA is also used by men for erectile dysfunction (ED), and by healthy women and women who have low levels of certain hormones to improve well-being and sexuality. Some people try DHEA to treat systemic lupus erythematosus (SLE), weak bones (osteoporosis), multiple sclerosis (MS), low levels of steroid hormones (Addison’s disease), depression, schizophrenia, chronic fatigue syndrome (CFS), and to slow the progression of Parkinson’s disease. It is also used for preventing heart disease, breast cancer, diabetes, and metabolic syndrome.
  • Low Dose Naltrexone (LDN) – 4.5 mg – an opiate antagonist, Naltrexone was approved by the FDA (at a 50mg dosage) in 1984 for opiate addiction, and again in 1995 for alcohol abuse. At a much lower dose (1.75-4.5mg), it has been gaining popularity as a treatment for symptoms of auto-immune disorders such as Multiple Sclerosis. It is believed that LDN briefly obstructs the effects of brain endorphins (the brain’s natural painkillers). Sensing an endorphin deficit, the pituitary signals for increased production of endorphins, which re-balances the immune system, thus reducing the activity of the MS. The effect lasts around 18 hours.
  • Vitamin D – 6,000 IU – Vitamin D, also known as the ‘sunshine vitamin’, is a steroid hormone precursor. It was originally thought to play a role only in the mineralization of bones and teeth by maintaining the correct phosphorous/calcium ratio. But over time research has linked low vitamin D levels with obesity, diabetes, depression, cardiovascular disease, autoimmune disease, osteoporosis and cancer. According to the CDC, in 2006 a whopping one fourth of the population was deficient in vitamin D. Gave me migraines for a long time – possibly due to intestinal die-off. Stopped taking it after reading Morley Robbins’ vit D warnings and eventually restarted after seeing that my ceruloplasmin did not drop. I also sunbathe.
  • Pregnenolone – 10 mg – improves energy, vision, memory, clarity of thinking, wellbeing.
  • T3 (cynomel/cytomel) – 6.25 mg

Herbal and other

  • Black cumin seed oil (read the reviews!) – 6.9 g – an antiviral, antifungal, antibacterial and anti-inflammatory, its extract Thymoquinone and other components of Nigella Sativa may be neuroprotective, have antioxidant effects and protect against heart, liver and kidney damage as well as having possible anti-cancer effects.
  • CoQ10 – 300 mg – The synthesis of CoQ10 in the body requires methylation (this also accounts for deficits in a variety of other important substances, including carnitine, choline, and creatine). This oil-soluble, vitamin-like substance is present in most eukaryotic cells, primarily in the mitochondria. It is a component of the electron transport chain and participates in aerobic cellular respiration, functioning in every cell of the body to synthesize energy in the form of ATP. Ninety-five percent of the human body’s energy is generated this way. Therefore, those organs with the highest energy requirements—such as the heart, liver and kidney—have the highest CoQ10 concentrations. Meat and fish are the richest source of dietary CoQ10 and levels over 50 mg/kg can be found in beef, pork, and chicken heart, and in chicken liver. Dairy products are much poorer sources of CoQ10 compared to animal tissues. Vegetable oils are also quite rich in CoQ10. Broccoli, grape, and cauliflower are modest sources of CoQ10. Most fruit and berries represent a poor to very poor source of CoQ10, with the exception of avocado, with a relatively high CoQ10 content. If you take either form of Q10, some of it is readily converted to the other form to maintain this condition of equilibrium. The reason I call the older form of this nutrient energy-Q10 is because it is the form of Q10 that is used in your mitochondria3 to make energy. Not surprisingly, this rather simple and important fact is omitted by those trying to push the more expensive version. Furthermore, this energy-Q10 is turning out to be a major cell communication regulation molecule, as it has been shown to significantly activate over 694 different genes4! This includes the reduction of the primary inflammatory gene signal, NF-kappaB 5. The energy-Q10 form also enables you to activate uncoupling proteins6 when you exercise, increasing the amount of fat you can burn off. Hardly an inferior substance.
  • Curcumin – 1000 mg – the primary agent in turmeric, the main spice in curry, is arguably the most powerful herb on the planet at fighting and potentially reversing disease. It has so many healing properties that currently there have been 6,235 peer-reviewed articles published proving the benefits of turmeric and one of its renowned healing compounds curcumin. This puts turmeric on top of the list as one of the most frequently mentioned medicinal herbs in all of science and the next most popular studied herbs include garlic, cinnamon, ginseng, ginger and milk thistle. Of the 6000+ studies referencing curcumin, the most interesting finding is that when turmeric is compared to conventional medicine its benefits equal that of many pharmaceutical medications. My doctor asked me to take it for its anti-inflammatory properties for 30 days prior to starting Cholestryamine. I’ve since read that it’s also helpful in reversing leaky gut. If you have mercury toxicity, you should know that it is a thiol and may stir up your mercury causing you to feel ill.
  • D-Ribose – 5 g – D-ribose is a simple sugar molecule with a wealth of functions in human and animal biology. Perhaps its most fundamental role is as a component of ATP, the universal energy carrier in the body’s cells. ATP molecules store energy as they are built up and release it as they are broken down—the more energy a cell requires, the more ATP it consumes. In fact, humans “burn” an amount of ATP equivalent to their own body weight every day! Every single process undergone by living cells requires energy—even at rest, we are continually breaking down ATP molecules. And that means that we have a constant need for the components of ATP molecules, including D-ribose. Cells can make new supplies of D-ribose, but the process is considerably slower than the breakdown of ATP—this can leave a substantial “deficit” in the amount of energy a cell can utilize. In fact, it has been shown that even an overnight rest period is not long enough for a person to recover their normal ATP levels after a bout of strenuous exercise. When cells don’t have enough D-ribose to restore ATP levels quickly back to normal, they turn to alternate energy-generating processes. These are less efficient and produce much higher levels of damaging waste products that cause muscle burning and cramping and that can also inflict long-term damage through the oxidant stress they induce in muscle and heart tissues, leading to further dysfunction, injury, and pain. Fortunately, research is demonstrating that ATP levels can be speedily brought back to normal if sufficient D-ribose is available. Starting dose for people with fibromyalgia – 15 to 30 g per day. According to Freddd, D-Ribose “enhances adenosylb12, l-carnitine, alpha lipoic acid, improves exercise recovery and energy.”
  • Kidney cleansing herbs – I use Dr. Christopher’s and hydrangea once a year or less.
  • Milk thistle – 3 caps (for liver support)
  • Monolaurin (read the reviews!) – 5.4 g – first on Dr. Ettinger’s biofilm protocol for lyme and gut, monolaurin is a non-ionic surfactant¹, which possesses an even greater anti-viral and anti-bacterial activity than its precursor, lauric acid. Monolaurin, when given orally, at therapeutic doses between 2,500 – 4,500 mg/day is generally well tolerated, with loose bowels as the only negative concern. Monolaurin has been studied at medical research centers, including the Center for Disease Control (CDC), because of its high antimicrobial (anti-viral, anti-bacterial, anti-fungal, anti-yeast and anti-protozoal) activity. These studies have provided information about the anti-viral and anti-bacterial mechanisms of monolaurin. Monolaurin was found to be effective against certain Lipid Coated Bacteria (LCBs) and Lipid Coated Viruses (LCVs) – enveloped DNA and RNA viruses. Studies have shown that monolaurin is able to remove all measurable infectivity by directly disintegrating the protective bacterial and viral lipid envelop. Binding of monolaurin to the viral envelop also makes the virus more susceptible to degradation by host defenses, heat, or ultraviolet light.
  • Probiotics – sometimes as much as 100 billion CFUs or more – divided with meals – Saccharomyces Boulardi, Megaspore and others
  • Reishi – 1 capsule, immune support often recommended for Canidida infection
  • Tempol – 150 mg – a superoxide dismutase mimetic that belongs to a class of non-thiol-containing radiation protectors, and has the ability to permeate the membrane. Read more here, check out the patent or learn the chemistry.
  • Vitamin K complex – 1 mg (mk-7 for low calcium) – Your body needs vitamin K for two important reasons; to help wounds heal properly, by making sure your blood clots, and to keep your bones strong and healthy. There is also some research which shows that vitamin K may help to protect against developing conditions like heart disease, prostate cancer and Alzheimer’s disease. Vitamin K is important in making sure that the calcium you get from foods or supplements is used in your bones. Vitamin D and vitamin K work together to strengthen your bones and to help them develop properly. There are two main types of vitamin K: Vitamin K1, which comes from leafy green vegetables like kale, chard and spinach. Vitamin K2, which comes from meats (organ meats in particular, such as liver), eggs, insects and hard cheeses. This type of vitamin K2 is called MK-4. There is also a different kind of vitamin K2, called MK-7, which comes from natto.
  • PQQ 20 mg – has been shown to induce mitochondrial biogenesis. While CoQ10 optimizes mitochondrial function, PQQ activates genes that govern mitochondrial reproduction, protection, and repair. PQQ also affords potent cardioprotection and defense against neuronal (brain) degeneration. Published studies show that 20 mg of PQQ plus 300 mg of CoQ10 may reverse age-related cognitive decline in aging humans.
  • Quercetin (bioflavinoid complex)1 cap – belongs to a group of plant pigments called flavonoids that give many fruits, flowers, and vegetables their color. Flavonoids, such as quercetin, are antioxidants. Quercetin acts like an antihistamine and an anti-inflammatory, and may help protect against heart disease and cancer. Quercetin can also help stabilize the cells that release histamine in the body and thereby have an anti-inflammatory effect. Both animal and human data suggest quercetin stimulates mitochondrial biogenesis. In the most recent study, published in February 2010, the Boone group used quercetin alone, but not in athletes. Instead they conducted their trial with untrained individuals. Even without the addition of green tea and fish oil, they reported a distinct benefit. In this study, 26 adult males took quercetin (1,000 mg/day) or a placebo. They were given 12-minute time trials on treadmills. Those taking quercetin went almost 3% farther during their 2nd time trial, while those taking placebo actually went about 1% less than their initial distance on their 2nd attempt. Some of the studies about quercetin’s effect on exercise performance have paid particular attention to the effect on mitochondria and suggest a novel clinical use: increasing mitochondrial function within cells. If this proves true, then quercetin may not only be useful to increase performance, but also potentially to treat fatigue of mitochondrial origin.
  • Trimethyglycine (TMG) – 1,000 mg (methylation support, protects liver cells from toxins, may increase alertness and mood)
  • S-Adenosylmethionine (SAMe) – 800 mg- is a naturally occurring compound that is found in almost every tissue and fluid in the body. It is involved in many important processes. SAMe plays a role in the immune system, maintains cell membranes, and helps produce and break down brain chemicals, such as serotonin, melatonin, and dopamine. It works with vitamin B12 and folate (vitamin B9). Being deficient in either vitamin B12 or folate may reduce levels of SAMe in your body. Numerous scientific studies have shown that SAMe helps relieve the pain of osteoarthritis, and other studies suggest that SAMe may help treat depression. Researchers have also examined SAMe’s use in the treatment of fibromyalgia and liver disease, with mixed results. SAMe has been on Life Extension’s TOP TEN list (for 15+ years) of the most important steps to take to ensure optimal longevity. SAMe has been recommended to aging individuals not to just feel better, but also to protect the brain, liver, joints, and other tissues of the body like no other substance.

Minerals and elements

  • Adrenal Cocktail – Capsules with Whole-Food Vitamin C, Potassium, and Redmon’s Real Salt.
  • Boron chelate – 6 mg – vitally involved in bone metabolism. Boron is distributed throughout the body with the highest concentration in the parathyroid glands, followed by bones and dental enamel. It is essential for healthy bone and joint function, regulating the absorption and metabolism of calcium, magnesium and phosphorus through its influence on the parathyroid glands. A borax supplement will reduce the daily loss of calcium by nearly 50%. Boron is for the parathyroids what iodine is for the thyroid. Enhances Vitamin D, inhibits enzymes that mediate the inflammatory cascade and are pertinent to therapies directed against inflammatory conditions, appears to play a significant role in human brain function and cognitive performance, and that it is an essential nutrient. Boron elevates circulation of serum concentrations of testosterone. Signs of possible deficiency include ADD/ADHD, osteoporosis, arthritis, fatigue, decreased motor function, decreased short-term memory, decreased brain function, and increased loss of calcium and magnesium in the urine. Reacts with Fluorine, Bromine and Chlorine as per Dr. Orlee. Non Toxic: Doses up to 18 mg of boron daily appear to be safe for adults even if taken for prolonged periods of time. An excellent fungicide it is being successfully used to treat Candida. With low to medium­ weight people use 1/8 teaspoon of borax powder and with heavier weight 1/4 teaspoon per litre of water. One drinks the water spaced out during the day, and does this 4 or 5 days a week as long as required. Listed peripherally on companion nutrients for iodine page.
  • Calcium – 65 mg (as calcium ascorbate, 55 mg per capsule) – In AI, Dr. Cutler says “mercury and other heavy metal toxins (including methylmercury) interfere with calcium metabolism.” and he recommends 500 mg per day.
  • Chromium polynicotinate – 1,200 mcg – in some studies chromium supplementation has been shown to improve some measure of glucose utilization. Blood sugar metabolism is often deranged by mercury and Dr. Cutler recommends 200 mcg with every meal plus some extra for 1000 mcg a day.
  • Iodine – 50 mg Iodoral (keep away from Vit C) – I was clearly deficient in iodine before titrating up as evidenced by the rise in my body temperature. The Weston Price Foundation discusses iodine with this preface: Iodine is critical to human health, forming the basis of thyroid hormones and playing many other roles in human biochemistry. While the thyroid gland contains the body’s highest concentration of iodine, the salivary glands, brain, cerebrospinal fluid, gastric mucosea, breasts, ovaries and a part of the eye also concentrate iodine. In the brain, iodine is found in the choroid plexus, the area on the ventricles of the brain where cerebrospinal fluid (CSF) is produced, and in the substantia nigra, an area associated with Parkinson’s disease.
  • Lithium orotate – 5 mg per week – lithium deficiency is commonly found with mercury toxicity and my hair test shows a good example. Small amounts of lithium have been found useful for improving mood, and lithium is known to function in iodine management and as a neuroprotective agent. Some find it causes a touch of brain fog and take it at bedtime for that reason (dosing discussion here).
  • Magnesium malate – 1200 mg (malate might chelate aluminum) – Magnesium is needed for more than 300 biochemical reactions in the body. It helps maintain normal muscle and nerve function, keeps heart rhythm steady, supports a healthy immune system, and keeps bones strong. Magnesium also helps regulate blood sugar levels, promotes normal blood pressure, and is known to be involved in energy metabolism and protein synthesis.
  • Magnesium threonate – use just occasionally for headache – scientists have been challenged to find a way to raise magnesium levels in the brain. Even intravenous infusions cause only a modest elevation of magnesium levels in the central nervous system. Researchers from the Massachusetts Institute of Technology (MIT) recently found a way to surmount this obstacle. They formulated a new magnesium compound called magnesium-L-threonate or MgT that in lab tests allows for oral administration while maximizing magnesium “loading” into the brain. Based on prior research, they meticulously documented that increased levels of magnesium in the brain promote synaptic density and plasticity in the hippocampus. Up until now, however, no widely available forms of magnesium met the criteria needed for rapid absorption and efficient transfer into the central nervous system. By contrast, MgT yielded compelling results. MgT oral supplements increased magnesium levels in spinal fluid, an index of measurement in brain magnesium by about 15%, while none of the other magnesium compounds tested produced significant elevations.8 While a 15% increase may not sound like a lot, it induced a profound effect on neurological function. MGT has been shown to enhance memory and cognitive performance in multiple tests and anecdotally to improve sleep.
  • Manganese – about 100 mg (if I take less, my RBC Mn goes low in labwork, and if I take none, Mn becomes undetectable by the lab) – Manganese is a trace mineral that is present in tiny amounts in the body. Consuming more than 11 mg per day of manganese could cause serious and harmful side effects. It is found mostly in bones, the liver, kidneys, and pancreas. Manganese helps the body form connective tissue, bones, blood clotting factors, and sex hormones. It also plays a role in fat and carbohydrate metabolism, calcium absorption, and blood sugar regulation. Manganese is also necessary for normal brain and nerve function. Manganese is a component of the antioxidant enzyme superoxide dismutase (SOD), which helps fight free radicals. Free radicals occur naturally in the body but can damage cell membranes and DNA. They may play a role in aging, as well as the development of a number of health conditions, including heart disease and cancer. Antioxidants, such as SOD, can help neutralize free radicals and reduce or even help prevent some of the damage they cause. Low levels of manganese in the body can contribute to infertility, bone malformation, weakness, and seizures. I have my RBC level checked monthly.
  • Molybdenum 300 mcg – according to Dr. Cutler, molybdenum is a cofactor for three enzymes often impaired in mercury toxicity. The biological form of the molybdenum atom is an organic molecule known as the molybdenum cofactor (Moco) present in the active site of Moco-containing enzymes (molybdoenzymes). In humans, molybdenum is known to function as a cofactor for four enzymes: 1- Sulfite oxidase (known to be crucial for human health) catalyzes the transformation of sulfite to sulfate, a reaction that is necessary for the metabolism of sulfur-containing amino acids (methionine and cysteine). 2- Xanthine oxidase catalyzes the breakdown of nucleotides (precursors to DNA and RNA) to form uric acid, which contributes to the plasma antioxidant capacity of the blood. 3- Aldehyde oxidase and xanthine oxidase catalyze hydroxylation reactions that involve a number of different molecules with similar chemical structures. Xanthine oxidase and aldehyde oxidase also play a role in the metabolism of drugs and toxins. 4- Mitochondrial amidoxime reducing component (mARC) was described only recently, and its precise function is under investigation. Initial studies showed that mARC forms a three-component enzyme system with cytochrome b5 and NADH cytochrome b5 reductase that catalyzes the detoxification of mutagenic N-hydroxylated bases. Dr. Cooter writes: Within days of taking 100 mcg of molybdenum three times a day, I could feel the poisons from candida garbage transforming themselves into heat and energy. Where I had experienced pain in my neck and shoulders, I felt warmth. A stiff back that felt like a wall of steel was transformed into copious sweat. My muscles relaxed and were pain free. At the same time, the person I was who found it difficult to get out of bed, became someone who needed 4 to 8 hours of sleep rather than 10 or 12. Where I had been confined within a prison of fatigue, the fatigue was translated into an open expanse of energy and possibility. An intellectual fog that had filled my head for years scattered itself the first day I took molybdenum. I had lived with an intellectual hangover for so long, I had no idea what it was like to experience full mental clarity. Dr. Cooter subsequently organized an informal study and found 2/3 of the participants had positive results (study measured chronic fatigue, weakness, joint pain, muscle pain, mental concentration, memory, depression and insomnia).
  • Potassium gluconate – 1000 mg – listed on Freddd’s methylation protocol as an absolutely critical supplement for basic healing to insure against hypokalemia (potentially fatal) triggered by sudden healing. I have taken as much is 5.3 g per day. Symptoms include weakness, lack of energy, muscle cramps, stomach disturbances, an irregular heartbeat, and an abnormal EKG. Hypokalemia is usually caused by the body losing too much potassium in the urine or intestines; it’s rarely caused by a lack of potassium in the diet. Potassium is a very important mineral for the proper function of all cells, tissues, and organs in the human body. It is also an electrolyte, a substance that conducts electricity in the body, along with sodium, chloride, calcium, and magnesium. Potassium is crucial to heart function and plays a key role in skeletal and smooth muscle contraction, making it important for normal digestive and muscular function. Many foods contain potassium, including all meats, some types of fish (such as salmon, cod, and flounder), and many fruits, vegetables, and legumes. Dairy products are also good sources of potassium. Side effects can include diarrhea, stomach irritation, and nausea. At higher doses, muscle weakness, slowed heart rate, and abnormal heart rhythm may occur. Contact your health care provider if you develop severe stomach pain, irregular heartbeat, chest pain, or other symptoms.
  • Selenium – 200 mcg x 2 – Dr. Cutler notes that selenium binds mercury tightly making less available for its other important roles. Toxicity can occur at fairly low doses so watch out for side effects like heart arrhythmias, insomnia and irritability. At the beginning of the 1990s it was discovered that the deiodinase enzymes which convert T4 (thyroxin, the thyroid prohormone) into T3 (triiodothyronine, the cellularly active hormone) are selenium enzymes (formed with the amino acid cysteine). This discovery has led to a lot of research studies on the effects of selenium, iodine, and their interactions revealing that selenium protects the thyroid from sustaining damage which can lead ultimately to cancer. Selenium also performs other important roles in the body – the most important of which is probably its role as the body’s best antioxidant (anti-peroxidant). It performs this role as part of glutathione peroxidase (GSHPx or GPX). As part of GPX, selenium prevents lipids and fats from being peroxidized (oxidized), which literally means that it prevents fats from going rancid (this can be seen on your skin as “age spots” or “liver spots” (autopsies show that skin “liver spots” are accompanied by similar spots of peroxidized fats in the liver.) Therefore selenium protects all of the cellular membranes, which are made up of fats, from peroxidation. Peroxidation of cellular membranes reduces the ability of the membrane to pass nutrients including minerals and vitamins, so selenium deficiency is the first step toward developing the many problems caused by nutrient deficiencies. Part of Dr. Klinghardt’s anti-retroviral recommendations.
  • Strontium citrate – 340 mg – for osteoporosis, on off-round days only – Strontium ranelate is registered as a prescription drug in more than 70 countries for the treatment of post-menopausal osteoporosis to reduce the risk of vertebral and hip fractures. In the United States, Strontium Ranelate is not approved by the FDA. I use strontium citrate which does not have a Wikipedia page yet but if you search online you will find lots of testimonials from people who’ve used it successfully to restore their bone density.
  • Vanadium sulfate – 10 mg (at breakfast) – improves insulin sensitivity and benefits may endure after use of vanadium sulfate is discontinued.
  • Zinc – 30 mg – according to Dr. Cutler, zinc is competitive with mercury and copper thereby diminishing some of their toxic effects – another way of saying this is that mercury can bind zinc and selenium, making them useless in the body and preventing them from doing their jobs. He also notes that zinc should be reduced from 100 to 50 mg after you start chelation with Lipoic Acid. Zinc is involved in numerous aspects of cellular metabolism. It is required for the catalytic activity of approximately 100 enzymes and it plays a role in immune function, protein synthesis, wound healing, DNA synthesis, and cell division. Zinc also supports normal growth and development during pregnancy, childhood, and adolescence and is required for proper sense of taste and smell. A daily intake of zinc is required to maintain a steady state because the body has no specialized zinc storage system.

To try

  1. Dr.Shades Etheric EDTA/ R-ALA formula
  2. ClearWay Co-Factors
  3. Sulbutiamine
  4. glutamine – helps keep the brain functioning according to Cutler and used by the liver to make blood sugar. It’s one of the amino acids in glutathione and best used (Dr. Cutler again) by taking four parts NAC, to two parts glutamine, to one part glycine between meals. confusing because Fred says to avoid all the glutathione precursors. Glutamine is the most abundant amino acid (building block of protein) in the body. The body can make enough glutamine for its regular needs, but under extreme stress (the kind you would experience after very heavy exercise or an injury), your body may need more glutamine than it can make. Most glutamine is stored in muscles followed by the lungs, where much of the glutamine is made. Glutamine is important for removing excess ammonia (a common waste product in the body). It also helps your immune system function and appears to be needed for normal brain function and digestion. Glutamine plays a role in a variety of biochemical functions: 1- protein synthesis, as any other of the 20 proteinogenic amino acids, 2- regulation of acid-base balance in the kidney by producing ammonium, 3- cellular energy, as a source, next to glucose, 4- nitrogen donation for many anabolic processes, including the synthesis of purines, 5- carbon donation, as a source, refilling the citric acid cycle, and 6- nontoxic transporter of ammonia in the blood circulation.
  5. glycineGlycine is an amino acid and neurotransmitter that serves both stimulatory and depressant roles in the brain. Three grams 1 hour before bedtime may improve sleep quality. Tastes like sugar. Per Cutler: an amino acid that aids in healing the digestive tract and boosting glutathione.


128 thoughts to “The supplements”

  1. Hi Eric, you’re probably not taking enough D for this to be an issue. I’ve been on 7000iu pd for years so this caught my interest. I don’t know whether this guy’s approach is full of holes or is completely valid but its an interesting listen. You’re taking a lot of magnesium potassium and vitamin A so I wouldn’t think this is a problem for you. I’m VDR Taq +/+ plus had surgery due to hyperparathyroidism tumors so have no idea how D3 fits into that – is good or bad. Cod Liver Oil is one source with a good A/D ratio so I may go there despite the bad press on fish oil.

    Also I found this on hydrogen peroxide which I’ve been considering doing. I have no idea what it means…..but its made me a little nervous about going there (which I am anyway).

    I see you’ve stopped taking manganese – can i ask why? With you SOD mutations isn’t manganese useful? Or do you have sufficient at this point? For your interest I came across this. No idea whether its relevant to you.

    And Morley Robbins is big on copper……

    I hope its ok for me to send you these random links above – I scan so much information and don’t understand half of it….but occasionally think I find something that may be of interest to the ongoing tweaking of your protocol or that is good to be aware of.

    One question I have – what form and brand of potassium do you take? You take it in high doses and I’m about to read your material on it. Its an issue for me….I’m working with methylation at the moment and am experiencing the deficiency of potassium and also folate it seems as I up my B2. Balancing the B’s is a real act!! If there’s not enough B1 or B3 …taking B2 can be a problem also. I just read the 43 pages on Phoenix Rising on the pros of B2 and then another lot on the cons. Since using transdermal B2 in increasing doses I’ve not had a single headache or migraine but it is creating or exacerbating my folate and potassium deficiency.

    Have you thought of borax baths? I read boron is to the parathyroids what iodine is to the thyroid. I see you’re taking boron….I’m thinking of taking epsom salts, borax and bicarb soda baths……….

    If you have a source for the info on bentonite clay I’d be interested. I like clay – its been good for me and would like to use it ongoingly but of course am concerned of its potential to create a mineral imbalance as you suggested is a possibility.

    You take a LOT of benfotiamine – any reason that type? I’ve read it can be good for nerves….I have nerve pain so wondering….I have a bottle of allithiamine but don’t know enough about the various kinds. Wondering why you chose that. And out with the biotin?

    Lots of questions – hope the ozone is going well! Thanks Eric for your responses to date!

    Best to you. Elizabeth

    1. Our body needs copper and zinc at a balanced proportion. The mineral that is helping to maintain this balance is molybdenum. If you are taking too much copper, not only will the copper/zinc balance be disrupted, but also your molybdenum will be depleted. The food that we eat today has way more copper than zinc; unless you eat plenty of oysters. I’ve been on copper supplement before, recommended by a naturopath. It was misguided.

      1. I’ve been on 3mg of Moly, now cutting back to 1.5 – I think that’s a lot…

  2. For me doing so many protocols and diets all at the same time it can be hard for me to see what’s improving what or worsening what. I stopped the MSM and the D at the same time so don’t know which reduced my headaches this time round.

    Re your headaches/migraines you’ll have looked into the tyramine/glutamates/sulphites/nitrates connections to headaches and toxicity? I can’t have anything aged or fermented, sauces & commercial stocks, animal protein thats been around for more than a couple of days…even then…..(histamine?), citrus, tomatoes plus I’m low oxalate/salycilate etc….. Also with a life of migraines as a female, it was also not being able to downgrade estrogen etc also. I resorted to imigran for most of my life. I think my ammonia for which I think the charcoal is good comes from something to do with not dealing with animal protein – for high ammonia they say go on a low protein diet.

    I don’t know what ozone therapy is. Do you have a link? I bought an ozonator recently to ozonate food and water but haven’t started using it yet.

    With the clay it can perhaps be useful on and off. I stopped for awhile because my body developed an aversion to it……..and I’ve only gone back to once a day every now and then for the moment. But it was generally a very positive experience. A lot of listening to the body involved.

    Amazing you still are feeling so toxic after all the chelating and cleansing and all the supps you take………genetics?? Genes not functioning properly? Is hydrogen peroxide similar to CD or MMS? If it is I’ve heard some people get terribly sick on that protocol. Maybe its managed better these days but in the earlier days of its use it sounds like it was pretty diabolical for some anyway.

    Best to you, Eric. The body can only take so much change and pushing………I hope you get chances to rest and let it all stop for awhile….

    1. Thanks Elizabeth, I actually decided to take the weekend off ozone:)

      Check out

      Yes it is amazing that two years of cleansing has not been enough but it’s very common for people with heavy metal toxicity to require four years or more of steady chelation. I will have taken a year off of chelation probably so when I go back to it I’m sure I will still have a couple years to go…

      As for the migraines, mine were completely unaffected by diet.

      Yes hydrogen peroxide is similar to CD/MMS but my experience shows that most of the things that make me feel ill do so because they trigger healing, cleansing and detoxification.

      1. Yes I agree with that last statement.

        I haven’t done a lot of chelation – some with EDTA and a little with DMSA and then homeopathics but not the ongoing regular grind that you’ve done. I guess that might be next………..grrrrrrrr. I don’t suppose ozone helps with chelation…I’d like to find an easy way for once….I know that’s not being realistic. Best to you.

        1. Dr. Slade promotes an easy way to do chelation but it’s very expensive and who knows if it really works. There are some good reports however and I haven’t ruled it out.

  3. Another thing Eric, I noticed you mention somewhere that you take charcoal 30 – 60 minutes after food. I was told to take 3 hours away from food as it can absorb good nutrients as well as bad elements. Do you use it every day. When I do, it certainly makes everything in the system go quiet. I started looking into it in regards to absorbing excess ammonia – I think this may be what happens sometimes when I eat animal protein and get a headache from it. Plus I have some gene snps that affect my downgrading of ammonia………or something like that!

    1. I have been experimenting with the timing of charcoal and honestly I’m not that concerned about nutrient absorption now. Toxins are so intense that sometimes when I feel the need for charcoal, I don’t care about anything else except getting a little relief! I do try not to take charcoal two days in a row. Have probably been using it to her three times a week.

  4. Hi Eric, I want to know why you have an aversion to bentonite clay. I’ve been using it for about 5 months x 2 pd and its been good…….helps to calm and regulate the bowel etc. It all functions better when I use it than when I don’t and I feel it does help with headaches. And on doing research I can’t find any solid information on the aspect of aluminium being absorbed – in fact all decent information seems to be to the contrary. Do you have information indicating this?

    Also K2 – 7 – I’ll looking for a good product but can’t find one that’s of a standard I’m happy completely with. Which one do you use? Ideally non GMO, non soy but there aren’t a lot of non soy out there and they seem to have quite a few additives. I think I may go for Jarrow which still is soy.

    I’m so interested to see the supplements you’ve cut out. That’s says almost as much as the ones you’ve left in and would so like to know why you stopped many of those. Perhaps they did their job and were no longer needed……. But that would be a long message. I’m going it alone, trying to work out which supplements are good though I’m tired of feeling like my body is being used as a laboratory. I guess thats where testing is useful. I’ve been to SO many practitioners and from where I sit now I feel like they are all experimenting as well….or else are stuck in the past without cutting edge knowledge. The doctor I went to re my migraines and 23 and me results started me off on 5mg of folate which made me so ill……..she had no idea about starting low and going slow.I’ve been taking a horrible K2 product and 7000iu D3 as well as D in some transdermOils and am only just finding out how bad these could be for me…..way to much D! I’ve been taking it for years on some integrative doctors recommendation. Its pretty hard to know what’s good and what isn’t without expert advice.

    A link in your site led me to Phoenix Rising where I read 43 pages (5 – 10 posts per page) about B2 (and manganese and K2 etc)…..B2 is a big one for me (I think, I hope) and I thought of you quite often while reading the material. But you’re on 100mg a day so that’s good and I know you say you didn’t have any good results with it.

    One thing I’m dealing with is nerve pain from an accident and subsequent failed surgery. I used to be a dancer and Feldenkrais practitioner but the last 8 years have been chronic pain……..that’s what started me on the trial to reduct inflammation in my body……and so to methylation etc etc etc….down the rabbit hole I went, and down the rabbit hole I still am.

    Best to you Eric. You’re kind to document all of this for others to gain insight from. Thank you.

    1. I couldn’t find anything conclusive about aluminum absorption from bentonite clay but I did find credible research that shows mineral balance being affected. I’m just being abundantly cautious for now. I know clay helps a lot of people. I use LEF’s K complex, it looked the best to me. As for supplements I’ve cut out, most of them it was because I had high hopes and after months of using them no big gains… In the end, I’m just doing the best I can as everyone else is, lots of guesswork. Some things I cut out I added back after reading research again that made me think I should take it even if I didn’t feel any better.

  5. Hi Eric yes I’ve just finished my first bottle of AOR probiotic 3 – I liked it…some bloating which may have been die off (how would I know) but my intestinal inflammation went right down. I’ve just received some Probiata Bifido from Seeking Health which has all the good Bifido strains evidently. I’m rotating the probiotics to see which ones work really well.
    I’m not sure why you’re not taking the mag that relieves your headaches regularly as opposed to occasionally? )

    1. great! I will be trying the AOR soon. that magnesium threonate seem to help with an ordinary headache but definitely did not prevent or stop mmigraines. And while it helped with the ordinary headache, I’m not sure the grogginess was worth it…

  6. Hi Eric, sorry if I came across as presumptuous about the oxalate etc……not intended just something that has helped me with inflammation and in finding a healthier balance going forward etc.
    Wondering why you only take the Mag threonate only occasionally instead of as your main mag source.

    1. not presumptuous at all. The magnesium threonate is expensive and makes me groggy. Just remembered I probably need to update my list to show that I’m taking magnesium carbonate now.

  7. Thanks Eric.
    No probiotics? I’m taking soil based probiotics and also some prebiotics. I think they’ve helped the gut. I’m VDR Taq +/+ as well so need to keep the biome happy I guess.

    1. actually I take huge quantities of probiotics and I better add it to the list because quite a few people have asked me already!

  8. Hi Eric!

    First of all, thank you so much for all that you’ve published! I’m finding a wealth of information here.

    I have a question about something you say about Thiamine (B1): “B-1 helps the liver process whatever doesn’t belong in your body.” I would like to know where you found this information, so that I can read more about how this works, which toxins B1 helps remove, etc. I’m curious because I’ve found B1 to be hugely beneficial, so I’d like to use the info to sort of “work backward” and figure out what my root problem is.

    Thanks for any research you can point me to!


    1. hi Michelle, glad to be of some help. I suspect that I was paraphrasing from Dr. Andy Cutler’s book, but I can’t check now because I lent it to my dad…

  9. Hi Eric, Thank You so much for sharing all what you have done/learned !
    I have methylation ‘gene problems’ but are only at the beginning of my journey so I’ve still a Lot to learn.
    Can I ask a stupid question..
    Why does >20 of the supplements on your list have their Names ‘crossed out’? example Vitamin D, CoQ10, Carnitine fumarate & Potassium, and for Vanadium sulfate all the info text is also ‘crossed out’..?

    1. That’s actually a good question Crimini – I need to update with the info. The strikethrough just means it’s something I’m not taking any longer for one reason or another. I have been trying to cut back steadily:)

  10. I noticed people wanting a way to eat coconut since they couldn’t tolerate other nuts. I make a treat similar to Almond Joy by adding a little over 1/2 cup coconut oil to 2 cups shredded coconut. Heat until oil is removed from shredded coconut, or you can cook until it browns the shredded coconut if you like it crispier. Divide mixture into mini muffin tins and refrigerate. Once solid, take out of tins and store in refrigerator in plastic bag or tupperware. I eat one after every meal. Helps with digestion and weight loss, plus, they are yummy! I just read your post. All of this is new to me. I know I have mercury toxicity because I had amalgams for 50 years, took birth control pills in early 70’s and had contact lens in the 80’s. I tried omitting thiols and found that they did exacerbate my chronic tiredness. I get the impression that you can go back to eating thiols after you chelate the mercury. How long does this take? Would eating thiols during chelation effect the chelation? Thanks for your input.

    1. Everyone is different Pat! Not everyone has problems with thiols. In the end, I don’t think they bother me particularly.

  11. I wanted to add that my doc (I have fibro and am trying to get out mercury) started me on iodine but it gave me terrible canker sores and I wasn’t able to tolerate it. He said iodine causes you to detox bromain and that was overwhelming me. There is a term called ‘salt loading’ and it means that the salt is used to dump the bromain into your kidneys so that it doesn’t just invade your tissues. It’s the chloride that does it. If you google the term you will see they recommend something like a quarter ts of celtic sea salt several times a day followed by 16 oz of water. I’m just starting this as I can’t tolerate even the smallest amount of iodine yet.

  12. Hi,

    I spoke with my doctor about my genetic mutations and methylation. She said that I should not take alpha lipoic acid because it is a sulfur donor and it disrupts mythylation. I’m curious if anyone has experience with heavy metal detoxification and jumpstarting methylation.


    1. Yes Rob, lots of experience with methylation and ALA. Taking alpha lipoic acid did not interfere with my methylation startup at all – in fact, it’s one of the supplements recommended by Fred as I recall. However it is also a strong chelator and Dr. Cutler advises that it needs to be taken every three hours in frequent doses around the clock, even during the night, to avoid redistributing mercury in the body. Many people have healed themselves from mercury toxicity this way. Look for Dr. Cutler information in the links on the right… I highly recommend his books. The one caveat is that frequent dose chelation may be too difficult for you if you have a weak / congested liver. I believe this is what happened to me.

  13. Hi, do you know where to buy dmps or which specific product has something similar? I did a quick search and didn’t see it online. Thanks

  14. Hi Eric

    Im pretty much in the same shoes, I tried pregnenolone the other day 10 mg caps – I was wondering what can cause pregnenolone to make you feel worse?

    + Eyes going so dry it feels like razorblades on the eyes
    + More fatigue
    + Zombie like

    Just to clarify I was not born a zombie! 🙂

    It went so bad so I didnt take another pregnenolone the second day.

    I read it could have something to do with sulfats but it is only a wild suggestion from another random community. Do you know the reason?

    Thanks Leon

    1. Followup question: did you take pregnenolone before or after you started detoxifying your body?

      I can imagine if ones body is filled with toxins and overall not having a good health adding a hormone precursor as pregnenolone might just make things worse.

      Anyway im putting a break on that supplement, tried it a 2nd time with awful symptoms.

      1. I started it after but I’m sure my body is still toxic… everyone reacts differently but I think that’s one you should discontinue if it makes you feel bad.

  15. Hi Eric, I have been slowly recovering and better understanding what happened to me… First it was lack of potassium (and also magnesium possibly), then high histamine from silymarin which got worse from shutting down methylation with niacinamide and stopping the mB12 and mB9… Now I am on a low histamine diet and next week will start a low dose B complex (from the local compounding pharmacy) and reintroduce the mB12 and mB9. Actually I am considering to try some folinic acid before reintroducing mB9. It is hard since I do not have a genetic test. I would like to ask if you have an opinion about this B complex

    1. glad it’s making sense to you. I don’t see anything wrong with that B complex…

  16. What a helpful website, thank you,  Eric! I  have Hashi and MTHFR and other hormonal issues. I will study your website careful and make some notes. I will post question later, when I know what to ask about… Peace and thank you again, million times!

  17. Hey Eric,
    What is the exact measurement of the sunflower lecithin you take each day (like in teaspoons, tablespoons, etc.)?
    I’ve been taking it recently too and I definitely feel like there’s something to it, but I’ve heard you don’t want to push it too high either so just curious how much I can work up to.

    1. The lecithin that I take comes in 1.2 gram gel caps – I freeze them in order to cut them in half and then I take 3 of those halves each day, so that is 1.8 g. But I also take 4 of Mercola’s lipo C caps which also contain an unspecified amount of lecithin… I believe my dose is small compared to what most people take. I think it’s common to take 3.6 g or 3 caps.

      1. Ah I see. Mine is the liquid sunflower lecithin and I started off taking 1/2 teaspoon a day under the advice of a doctor I had been talking with that specializes in these genetic mutations. She then told me to cut back on it a bit after a few weeks and go down to 1/2 teaspoon every few days.

        I wasn’t sure of the reason for cutting back though because I definitely feel like it helps a little when I take it. Do you have any ideas?
        How much choline specifically are you getting from your 1.8 grams of lecithin per day? The stuff I have is 2100 mg choline per tablespoon so I’d say I’m getting around 350 mg of choline in 1/2 teaspoon.
        I have a few other questions if you don’t mind:
        1. I know the Enzymatic Therapy is the current recommended MeB12 and a separate AdB12 as well, but Dr. Lynch’s B12 (Seeking Health) just got reformulated it looks like and is now a mix of 4,000 mcg MeB12 and 1,000 mcg AdB12 so I ordered that. I know his stuff is high quality and since he’s a specialist in mutations as well, his brand should be perfect, so I’m curious why I never see that brand recommended and if you or anyone has experience with it.
        2. Regarding potassium, I’m kinda confused because the bottle I have says 550mg potassium gluconate but only 90mg of that is elemental if I understand it correctly. When you say you’re taking 5300 mg, are you basing that on the bigger number on the bottle (so roughly 10 pills per day) or the elemental number which would be like 50 pills per day? I’m guessing the first one but just unsure because I thought I saw someone mention they base it off the elemental number.
        3. I’m also taking the Optimal Multivitamin from Seeking Health which has a little L-Cysteine/N-Acetyl L-Cysteine in it (75 mg). I know those are glutathione precursors and I’ve seen it recommended not to take glutathione but are these precursors all right if I’m not doing too many of them?

        1. I don’t have any idea why you would want to cut back… The only negative I know about is that it stimulates the adrenal glands which for me was like using caffeine – after the buzz wears off, I’m exhausted. that’s why I take less than normal, but I seem to be adapting to it well now. looks to me like I’m getting 315 mg of phosphatidylcholine from this. 1- no idea. 2. My 5300 mg of potassium are elemental, so yes I take a LOT of potassium pills. Some of it is in the form of potassium chloride which I put into my own capsules. 3. I couldn’t say – you’ll have to experiment!

          1. Cool thanks for the responses Eric. And yeah that is a lot of potassium lol. I didn’t realize our needs could get that high.
            I’ll start testing and see what happens.

  18. Hi,
    May I ask what brand of DMSA you are taking? I have almost no symptoms with the VRP DMSA 50mg and it was suggested to me that it’s not potent. Thank you.

    1. hmmm, I’ve never heard that before. When I open each bottle they are very smelly and they cause me plenty of side effects!

  19. Eric, have you seen the conversations from late 2012 to 2013 on Phoenix Rising, in which people discuss a formula change in the Jarrow brand of methyl-B12…a formula change that unfortunately many people found to result in failure for them?  Just wondered, in case you are using Jarrow as your methyl B12 — I’ve read so many people’s notes about the Jarrow just not working well for them anymore.  There is also a poll/survey on Phoenix Rising asking what brands people are using and did they find them effective; the Jarrow change in formulation is noted there as well, I believe.

  20. Are all these supplements taken while chelating? For example, should I stop taking magnesium during my 3 days chelating, and only supplement during my 4 off days? I was under the impression that I should not be supplementing with magnesium and potassium during chelation days. Anybody know what Andy says about supplementing while chelating? thanks!

  21. Do you seriously take all of these supplements?  I read most of what your have documented but became overwhelmed before I could get to the end.  I have the C677T Hetero.  I have recently been weaning off an anti depressant for depression due to so many side effects.  I have tried various supplements, hormones, etc.  All cause side effects.  I feel/felt terrible on anything, but feel terrible as I try to get off of them too.  So I have been trying to clear out my system of hormones, supplements and medicines; hoping to get a fresh start without hitting rock bottom with depression again.  I have been diagnosed as being overly sensitive to most any substance I put into my body. Most Doctors and natural paths get frustrated treating me because I don’t fit into the ‘A typical” treatment. 
    Maybe you can comment on these: I take Vitamin C and do not seem to have any noticable side effects. Except that I do notice  a soreness under my rib cage that goes away with 1,00 to 2,000. I have taken kelp as iodine alone and feel fine for a few days then I become what seems to me as over energized and wired.  However, I have much better focus and motivation   I have taken kelp as iodine with selenium at 100mcg/100mg.and also DHEA drops at five drops a day.  I felt a little better, but I was also on medicines, other supplements and kept having a combination of hopeless feelings and became irritable .  After seeing an endroconologyst I was told to stop the iodine and DHEA, (the dhea was for my adrenals.) I felt a noticeable drop in my already low mood. I have taken selenium alone and broke out in a terrible rash. I have eaten just a few brazil nuts and gained energy with no other noticeable side effect.
    I am presently still on triple fish oil and E-400, and C-1000, weaning off of sertraline for depression and still on clonazopam .25 night and half of that as needed during day.
    Don’t feel bad if you can not comment on this it pretty complicated I am sure.

    1. Hi Matina, I was traveling when your message came in but I do have a few late comments for you in spite of the fact that I don’t know a thing about genetics yet. First, I’m tempted to say something very mean about endocrinologists, that in my experience, they are the dregs of the medical profession. But, that’s too extreme – a more polite and correct way of saying it is that they are, in my experience, very poorly equipped to help someone with a chronic health problem. Don’t expect to get good advice from an endocrinologist.

      The second thing I can tell you from my experience is that I don’t think I could do any healing while on benzodiazepines. My body was extremely dysfunctional while I was on diazepam and lorazepam. I was so weak physically I could not comfortably walk six blocks. My doctor actually offered me Klonopin and after researching it on I decided it was way too dangerous. So I would just recommend you not get your hopes up for any significant healing until you have tapered off benzodiazepines. Sounds like you’re on the right track there. Have you tried glycine and gaba as a substitute when you get anxious? They both helped me.

      Hang on and you’ll get there!

      As for all the supplements I take, yes it is a bit overwhelming because I divide them up throughout the day and night. I do still experience some side effects from them after meals. I get drowsy and sometimes have to nap after lunch…

  22. Eric, what’s your experience with IsoCort? I have a adrenal insufficiency and I already tried pregnenolone and licorice but it seems like it doesn’t really help (probably because the brain signals are garbled). I’m very hesitant to add cortisol in my supp regimen, but I was thinking if it helps me chelate and prevent crashes, it might be good for the long-term. Thanks.

    1. I’ve used Isocort for somewhere between five and seven years with a break in between of a couple years. I’m just not functional without it… I wish it weren’t so, and I hope I will be able to taper off it after finishing chelation!

  23. Took my first SAMe today and increased my fish oil to 923 mg of omega-3… SAMe is the last methylation supplement on my list. Now that I’m taking them all, I’ll turn my attention back to increasing folate and mb12. So far, it feels like all of the methylation supports do the same thing at first – make me feel a little wired and tired with a mild headache or head pressure and sometimes a little lightheaded.

    1. Eric, how did you decide in what order to add each supplement/type of supplement?  I’m tempted to grab a jar, and in it dump the insides of a variety of methylation support supps, a variety of the special forms of the b vitamins, and each of the amino acids that all may be the weakest link in myself, shake the jar to mix all these powders, then take a tiny bit of the blend each day.  And increase that tiny bit slowly.  Ha.  That might be better than all my notes trying to plan it out!  Only half kidding here.  Any tips on deciding sequence of adding things?  (Assuming that the person isn’t chelating, to keep it a little simpler)

      1. It hasn’t been easy – I am still making these decisions every day, although now it’s more about increasing amounts or changing the timing, than adding. I use a lot of intuition and trial and error.

        Here’s how I would recommend doing this for someone likely to have reactions to these supplements (roughly speaking):

        first, start the essentials: vitamin C, D, E, A, omega-3, magnesium and zinc. spend a few weeks working these up.
        second, the B complex from pure encapsulations: one a day at breakfast for three or four days, then add a second at lunchtime. wait a week before moving to the next stage.
        third, the b12s: 1/8 tablet source naturals dibencozide upon waking for a week, then add 1/8 tablet mb12 – work these up slowly for a few weeks before moving to the next stage.
        fourth, the cofactors: introduce small amounts of coQ10, carnitine fumarate, TMG and SAMe in that order.
        fifth, metafolin: start increasing your folate slowly.

        this is based somewhat on my experience and someone on what I’ve read about all this – trying to save the supplements that cause the biggest reactions for the later stages…

  24. When reading your well-done blog, I wondered why I don’t see manganese (manganese, different than magnesium).  Dr. Cutler includes it in his list of supps to take to reduce copper, if people have high copper levels.  After a recent reaction to a small experimental dose of manganese (my reaction was symptoms concurrent with increased acetylcholine), I’ve been trying to find the connection.  Cutler doesn’t go into detail on manganese that I can remember, beyond listing as part of the program to reduce copper, for copper toxic people.

    I stumbled on a posting by someone who had read liver biopsy results from a study on dogs.  This person posted under a screen name, and I haven’t had time to research further, but in their opinion the connection between manganese and copper could be:

    “The liver continues to accumulate copper in the lysosomes when it is deficient in choline and manganese. When these dogs are supplemented with these nutrients, they no longer are copper toxic and their liver enzymes return to normal.”

    If you have run into anything on manganese, I’d love to hear about it.  Your site is terrific!

    1. Thank you for stopping by and commenting Mary! I have just recently wondered about manganese and remembered that I used to take it 10 years ago before I knew anything about heavy metals.

      After seeing your comment, I re-read the manganese sections in AI and HTI and notice that manganese is crossed off the list of supplements to take. On FDC, the moderators are saying that this is because the window between deficient and toxic is so small, it’s not worth toying with.

      I’m sure I must’ve taken it years ago because of its role in normalizing blood sugar. I notice that the foods high in manganese includes nuts and seeds which I overdosed on for a few years and only stopped recently, so I’m guessing I probably should not experiment without getting some testing first.

      That said, it’s tempting because of Andy’s comment about chronic or acute inflammation which I definitely have.

      Let me know if you find out more about your reaction…

      1. On page 99 in Cutler’s book (AI), there’s one tiny sentence that says “taking zinc and manganese in a ratio of 20:1 will increase the urinary excretion of copper”.  He posted more recently online, saying to include manganese in a copper detox program, but I can’t find that post at the moment.  There is a nice site called onibasu that gathers the threads from a few select yahoo chelation boards together for easy searching.  Cutler’s posts are often in the onibasu site.  Here’s that link:

        If my own experiments turn up something useful about manganese, I’ll write a you a note Eric.  Best,  -Mary

        1. Thanks Mary, you’re very kind to share this info with me. I got a kick out of seeing Freddd’s post in the manganese thread. He turns up everywhere! I was surprised to see a possible connection with methylation via the mitochondria – makes me think I should give it a try:)

          It has been four months since I quit eating nuts now, so with a 40 day half-life my blood would be clear of it long ago. I wish there was some wayto know the status of manganese in the tissues… i guess trying the supplement might be the way!

          I searched using Onibasu and could not find the post from Andy you referred to.

  25. Added boron yesterday after reading about sleep, calcium and magnesium management benefits…

    1. I take 2 of these every day:
      I added it after about 12 months, so I have been on it for about 9 months now (I think). Some people over at the Iodine group on Curezone really likes Boron and claims that it is very important for the para thyroid and also that it can more or less cure candida. In my case, I don’t think that there has been any major effects but it is hard to tell with all these supps.

      1. I picked up the Solgar version which looks like it has the same ingredients and about the same price… Also decided to take it after reading the iodine companions page on cure zone. Funny thing is every time you write to me, I do a little more research and make changes in my protocol. Just found this and decided to increase my dose from 2 to 3 per day, maybe for three months or so…

  26. Have you tried Liposomal Vitamin C? I make my own with non-GMO lecithin granules and Sodium Ascorbate from NutriBiotic. I was also having a hard time tolerating C. Since taking the Lipo-C, I’ll never go back to another form. Easy and cheap to make, too. Viking, do you know about how many grams are in each ounce of Lipo C? I take 2 oz. daily, and haven’t been able to figure out how many grams that would be…

    Also, I’m going to try switching over to a Solgar selenium supp, from my usual brazil nuts. From what I’m reading, the selenium content per nut can very considerably, and with concern for overdosing on it, I’d prefer controlling it to a greater degree. Especially with needing to balance it out with the Iodine.

    1. Tara, what kind of reaction did you have with other types of vitamin C? I don’t know anything at all yet about Liposomal… I also started selenium yesterday and Iodoral today (6.25 mg).

  27. Very low levels on some of the supps! Do you have difficulty tolerating?

    Vit C VERY low. My view would be 2-4 grams off round and double that on round. I use sodium acorbate from NOW, cheap and ok for my gut. But as with all other supps, there are lots of views out there….

    Magnesium is also low. I had great problems with this one (watery stools…) and are taking 400 mg Mag citrate a day, which is also on the low end. 600-800 mg would be better, I think.

    Also, you are missing many of the basic supps recommended by Cutler, i.e. the list on page 133-134 in his book. Is it on purpose?

    Finally, if you are going to do iodine, you REALLY should consider adding selenium.

    1. Thanks for the detailed feedback Viking. yes I am very sensitive to vitamin C and magnesium. vitamin C is a stimulant for me and increases my brain fog at the same time. unable to sleep if I take it to near bedtime also. I’m also using sodium ascorbate crystals. Magnesium gives me fatigue and I eat Brazil nuts for selenium.

      I don’t have Cutler’s first book, only the hair analysis book. I’m also very gun shy with supplements because I lived for several years with constant stomach pain and eventually discovered that it was coming from supplements though I don’t know which one(s). I don’t like starting so many new things all at once. Fortunately, at the moment everything seems to be going well.

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